What is a significant contraindication for administering aspirin?

A significant contraindication for administering aspirin is active gastrointestinal bleeding. Aspirin has anticoagulant properties, which means it can inhibit platelet aggregation and prolong bleeding time. In patients with active gastrointestinal bleeding, the use of aspirin could exacerbate the condition, leading to a greater risk of hemorrhage.

When aspirin is given to someone who is already experiencing significant bleeding in the GI tract, it increases the likelihood of more severe complications and can hinder the body's ability to stop the bleeding. Therefore, it is crucial to avoid administering aspirin in such situations to ensure patient safety and to prevent worsening of the bleeding.

The other options may present less immediate risks or complications compared to active gastrointestinal bleeding but do not constitute a strong contraindication for aspirin usage in the same way.