What position should the epinephrine auto-injector be administered?

The epinephrine auto-injector should be administered intramuscularly in the lateral mid-thigh because this route allows for rapid absorption of the medication into the bloodstream, which is crucial in emergency situations such as anaphylaxis. The thigh muscle has a rich vascular supply, enabling quick action of the epinephrine. Additionally, injecting into the thigh is practical and accessible, especially in individuals wearing clothing.

Subcutaneous injections can lead to slower absorption rates, which is not ideal in emergencies where swift intervention is necessary. While intravenous administration could provide rapid results, it requires specific training and equipment not typically available in emergency situations where auto-injectors are used. Finally, intranasal administration is not a standard method for delivering epinephrine, as effective formulations for nasal delivery are not commonly available for this drug. Thus, the chosen option is the safest and most effective method in cases of severe allergic reactions.